As Alzheimer’s disease It currently affects 7 million Americans (the largest number ever). There is growing demand for new treatments.
Scientists at the University of California, Irvine have discovered a “groundbreaking” new treatment to combat illness.
Treatment involves using stem cells to “program” human immune cells called microglia to counter the signs of Brain dementiaAccording to a press release from UCI.
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Microglia are immune cells found in the central nervous system, according to the re-craftsmen, that act as the “main line of defense against infection and injury” in the brain.
use CRISPR gene editingscientists engineered cells to produce an enzyme called neprilysin. This has been shown to break down toxic beta-amyloid plaques that accumulate in the brains of patients with Alzheimer’s disease.
Alzheimer’s disease is currently affecting 7 million Americans (the largest number ever), leading to increased demand for new treatments. (istock)
In mouse brains, engineered cells have been found to preserve neurons, reduce inflammation, reduce beta-amyloid accumulation, reduce inverse neurodegeneration, and reverse neurodegeneration, researchers have found.
The study, funded by the National Institutes of Health, was published in the journal Cell Stem Cell.
“I’m a neurologist – this is why dementia is rising and how to reduce the risk.”
“Deliverying biology to the brain has long been a major challenge due to blood-brain barriers,” says Mathew Blurton-Jones, professor of neurobiology and behavior, in this release.
“We have developed a programmable living coverage system that exists in the brain itself and avoids that problem by addressing only the places that are needed and wherever necessary.”
Programmed cells target only amyloid plaques, researchers point out, making the approach “highly targeted, but broadly effective.”
“We have developed a programmable living coverage system that exists in the brain itself and avoids that problem by addressing only the places that are needed and wherever necessary.”
This study also found that microglia is effective in fighting other central areas. Nervous system disordersbrain cancer and multiple sclerosis.
“This work opens the door to a whole new class of brain therapy,” says Robert C. Spiterle, professor of medicine science, in the release.
“Instead of using it Synthetic drugs Or viral vectors, brain immune cells are registered as precision delivery vehicles. ”
Using CRISPR gene editing, scientists engineered cells to produce an enzyme called neprilysin. This has been shown to break down toxic beta-amyloid plaques that accumulate in the brains of patients with Alzheimer’s disease. (istock)
Dr. Joel Salinas, a behavioral neurologist and associate professor at the NYU Grossman School of Medicine, said the study was highly targeted and responsive “impressive evidence of the concept.” Brain therapy.
“One of the most exciting aspects is accuracy. Instead of releasing treatments throughout the brain, these modified cells only activate when disease-related damage is occurring,” Salinas, who was not involved in the study, told Fox News Digital.
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“This type of targeting action helps limit harm to healthy brain tissue, reduce side effects, and focus treatment effects when needed most.”
The results are still early and limited to mice, but Salinas noted that this strategy opens up a “new promising path.”
The results are still early and confined to mice, but the strategy opens up a “new path of promise,” neurologists noted. (istock)
Looking ahead, researchers aim to conduct human testing. Stem Cell Use According to the release, from individual patients to reduce the risk of immune rejection.
“If future research shows that this approach is safe, durable and effective in humans, it could be adapted not only to Alzheimer’s disease, but also to other conditions in which the disease process is patchy or localized, such as brain tumors. Multiple sclerosis Or other neurodegenerative diseases that cause dementia,” Salinas said.
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Dr. Courtney Croske, director of scientific engagement at the Alzheimer’s Disease Association in Chicago, reviewed the results of the UCI study.
“Due to the continued aging of the population, strategic research funding is important to expand the treatment pipeline for Alzheimer’s disease and other diseases that cause dementia,” she told Fox News Digital.
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“It is equally important to explore a variety of drug delivery methods, including using genetically modified cells, as demonstrated in this newly published study.”
Kuroske noted that these findings are promising and hopeful, but preliminary.
“Additional research is needed to determine how this type of drug delivery mechanism affects individuals at or at risk for Alzheimer’s disease,” said a representative from the Alzheimer’s Disease Association. (istock)
“Additional research “This type of drug delivery mechanism is necessary to determine how it affects individuals who live with or are at risk with Alzheimer’s,” she said.
“This study was conducted in an animal model. The authors emphasize the importance of moving this study into clinical trials in people to better understand the therapeutic potential of this drug delivery mechanism.”
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In addition to the NIH, the study was supported by the California Institute of Regenerative Medicine and the Cure Alzheimer’s Fund.
