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potential treatments type 1 diabetes It was identified by scientists in a new mouse study.
In animal studies, researchers at Stanford University School of Medicine found that resetting the immune systems of diabetic mice and creating new insulin-producing cells reversed the disease in 100% of cases, according to a Stanford University press release.
The researchers took a group of 19 prediabetic mice and gave them a nontoxic “conditioning” treatment, including: low level radiation There are also special antibodies that reduce certain immune cells called T cells, the study says.
How to reverse prediabetes before it leads to type 2 diabetes
The goal was to reduce the reactivity of the mice’s immune systems so scientists could more effectively test new treatments.
The mouse then received: stem cells Transplantation using other mouse bone marrow cells and donor islet (insulin producing) cells.
The researchers detailed how type 1 diabetes occurs when the immune system “inadvertently destroys insulin-producing islet cells in the pancreas.” (St. Petersburg)
The researchers’ goal was to create “mixed chimerism,” or an environment in which the mice had both their own cells and donor immune cells.
As published in the Journal of Clinical Investigation, the method prevented the development of diabetes in all 19 prediabetic mice.
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The researchers also studied nine mice with long-term type 1 diabetes. All nine mice were cured by treatment that combined stem cells and islet transplantation.
The results showed nothing Main side effects Scientists pointed out that this could also be due to a weakened immune system.
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Although the study was conducted only in mice and required a certain amount of radiation, which may limit future research, the experts shared optimism that the treatment could eventually be applied to humans.
In addition to diabetes, this “gentler preconditioning approach” could make stem cell transplants “a viable treatment for autoimmune diseases such as: rheumatoid arthritis and non-cancerous blood disorders such as lupus and sickle cell anemia,” the researchers wrote.
The researchers reported that all mice in the study were cured of type 1 diabetes. (St. Petersburg)
“An important step in our research, creating animals with hybrid immune systems containing cells from both donor and recipient, is already being used in clinical settings for other diseases,” study co-author Seung K. Kim, MD, PhD, professor of developmental biology, gerontology, endocrinology, and metabolism and KM Mulberry Professor at Stanford University, said in a statement.
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“We believe this approach will be transformative not only for people with type 1 diabetes and other autoimmune diseases, but also for those in need of robust treatment. organ transplant. ”
“We believe this approach will be transformative for people with type 1 diabetes and other autoimmune diseases,” study co-authors wrote. (St. Petersburg)
Fox News senior medical analyst Dr. Mark Siegel commented on these findings in an interview with Fox News Digital, noting that while this is “preliminary research,” it could be promising for humans.
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“This is a viable approach and can be applied to human therapy, but it needs to be modified in the following ways. Genetic analysis “And artificial intelligence for a personalized approach to the autoimmunity that causes type 1 diabetes,” he said. “It’s not a one-size-fits-all.”
